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Publication Year: 2024

51 to 60 of 557 Results

ETs_seq_mod_noRedund.fasta.clstr Oct 16, 2024 - Experimental data on the binding and activity of 1,3,4-Oxadiazoles to Bromodomain factor 3 (TcBDF3) of Trypanosoma cruzi Unknown - 13.3 KB - MD5: b0b3e44257cb3fbf96ea0ab948ec68e9 Non redundant sequences of the extra-terminal (ET) domains in fasta format used in the phylogenetic tree. Secuencias no redundantes de los dominios extraterminales (ET) en formato fasta utilizados en el árbol filogenético.
filtering_analysis.py Oct 16, 2024 - Experimental data on the binding and activity of 1,3,4-Oxadiazoles to Bromodomain factor 3 (TcBDF3) of Trypanosoma cruzi Python Source Code - 12.9 KB - MD5: 1c795da7041525bbcf7734b77a1a42d6 Filtering strategy for the phylogenetic analysis. Estrategia de filtrado para el analisis filogenético.
final_BD-ET_tree.zip Oct 16, 2024 - Experimental data on the binding and activity of 1,3,4-Oxadiazoles to Bromodomain factor 3 (TcBDF3) of Trypanosoma cruzi ZIP Archive - 1.3 MB - MD5: e095e8e15199a7326b09b179be023917 Final phylogenetic tree constructed from multiple sequence alignments of the extra-terminal (ET) domains of the bromodomains (BD) selected from the search strategies in Foldseek. Arbol filogenético final contruido a partir de alineamientos de secuencias multiples de los dominios...
finalET_BD_jalviewMSA.fasta Oct 16, 2024 - Experimental data on the binding and activity of 1,3,4-Oxadiazoles to Bromodomain factor 3 (TcBDF3) of Trypanosoma cruzi Unknown - 33.5 KB - MD5: d4bd394f2c3d487ff018f80e3307d684 Archivo final del alineamiento de secuencias multiples de los dominios extra-terminales (ET) de los bromodominios (BD) en formato fasta. Final file of the multiple sequence alignment of the extra-terminal (ET) domains of bromodomains (BD) in fasta format.
Fluorescence_Polarization.tab Oct 16, 2024 - Experimental data on the binding and activity of 1,3,4-Oxadiazoles to Bromodomain factor 3 (TcBDF3) of Trypanosoma cruzi Tabular Data - 1.1 KB - 4 Variables, 34 Observations - UNF:6:nzsAXF6SCb6QGtQBi8BX4A== Fluorescence Polarization measurement was performed on a spectrophotometer equipped with a polarizer. Tables include raw data of Polarization versus concentration using the fluorescent probe BSP-AF488. La medición de polarización de la fluorescencia se realizó en un espectrofotóm...
Fluorescence_Quenching_A1B4.tab Oct 16, 2024 - Experimental data on the binding and activity of 1,3,4-Oxadiazoles to Bromodomain factor 3 (TcBDF3) of Trypanosoma cruzi Tabular Data - 384 B - 11 Variables, 4 Observations - UNF:6:IysjyZ3uTcwm5XXpdYijoQ== Table of three concentrations of A1B4 versus fluorescence intensity from the aromatic amino acids of TcBDF3, TcBD3, TcBD2, and TcBDF3m. As a positive binding control, iBET-151 was used, a BET bromodomain inhibitor previously reported to bind to TcBDF3. Tabla de tres concentrac...
hmmer_commands.sh Oct 16, 2024 - Experimental data on the binding and activity of 1,3,4-Oxadiazoles to Bromodomain factor 3 (TcBDF3) of Trypanosoma cruzi Shell Script - 147 B - MD5: c12c5eb5759ce13376632d76bdeed7d1 Commands used in the HMMER v3.4 search algorithm. Comandos utilizados en el algoritmo de búsqueda HMMER v3.4.
hmmsearch_output_dom.tab Oct 16, 2024 - Experimental data on the binding and activity of 1,3,4-Oxadiazoles to Bromodomain factor 3 (TcBDF3) of Trypanosoma cruzi Tabular Data - 82.4 KB - 16 Variables, 772 Observations - UNF:6:FC2Cqf6OhI3z+eOR3H00Ug== Table with the results obtained using the HMMER v3.4 search algorithm. Tabla con los resultados obtenidos utilizando el algoritmo de búsqueda HMMER v3.4.
hmmsearch_output_dom.txt Oct 16, 2024 - Experimental data on the binding and activity of 1,3,4-Oxadiazoles to Bromodomain factor 3 (TcBDF3) of Trypanosoma cruzi Plain Text - 142.7 KB - MD5: e3a4d664cb8d5f4371b26aaa0298a990 Output table of the search using the HMMER v3.4 search algorithm. Tabla de salida de la búsqueda utilizando el algoritmo de búsqueda HMMER v3.4.
MTT_cyclic.tab Oct 16, 2024 - Experimental data on the binding and activity of 1,3,4-Oxadiazoles to Bromodomain factor 3 (TcBDF3) of Trypanosoma cruzi Tabular Data - 229 B - 4 Variables, 9 Observations - UNF:6:2RyKD/w3ASTzF6ieve3XzQ== 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction assay determined cell viability after treatment. Table with absorbance measurements at 540 nm for increasing concentrations of A1B4c and A5B4c. El ensayo de reducción con bromuro de 3-(4,5-dimetiltiaz...

ETs_seq_mod_noRedund.fasta.clstr

Oct 16, 2024 - Experimental data on the binding and activity of 1,3,4-Oxadiazoles to Bromodomain factor 3 (TcBDF3) of Trypanosoma cruzi

Unknown - 13.3 KB -

Non redundant sequences of the extra-terminal (ET) domains in fasta format used in the phylogenetic tree. Secuencias no redundantes de los dominios extraterminales (ET) en formato fasta utilizados en el árbol filogenético.

filtering_analysis.py

Oct 16, 2024 - Experimental data on the binding and activity of 1,3,4-Oxadiazoles to Bromodomain factor 3 (TcBDF3) of Trypanosoma cruzi

Python Source Code - 12.9 KB -

Filtering strategy for the phylogenetic analysis. Estrategia de filtrado para el analisis filogenético.

final_BD-ET_tree.zip

Oct 16, 2024 - Experimental data on the binding and activity of 1,3,4-Oxadiazoles to Bromodomain factor 3 (TcBDF3) of Trypanosoma cruzi

ZIP Archive - 1.3 MB -

Final phylogenetic tree constructed from multiple sequence alignments of the extra-terminal (ET) domains of the bromodomains (BD) selected from the search strategies in Foldseek. Arbol filogenético final contruido a partir de alineamientos de secuencias multiples de los dominios...

finalET_BD_jalviewMSA.fasta

Oct 16, 2024 - Experimental data on the binding and activity of 1,3,4-Oxadiazoles to Bromodomain factor 3 (TcBDF3) of Trypanosoma cruzi

Unknown - 33.5 KB -

Archivo final del alineamiento de secuencias multiples de los dominios extra-terminales (ET) de los bromodominios (BD) en formato fasta. Final file of the multiple sequence alignment of the extra-terminal (ET) domains of bromodomains (BD) in fasta format.

Fluorescence_Polarization.tab

Oct 16, 2024 - Experimental data on the binding and activity of 1,3,4-Oxadiazoles to Bromodomain factor 3 (TcBDF3) of Trypanosoma cruzi

Tabular Data - 1.1 KB - 4 Variables, 34 Observations -

Fluorescence Polarization measurement was performed on a spectrophotometer equipped with a polarizer. Tables include raw data of Polarization versus concentration using the fluorescent probe BSP-AF488. La medición de polarización de la fluorescencia se realizó en un espectrofotóm...

Fluorescence_Quenching_A1B4.tab

Oct 16, 2024 - Experimental data on the binding and activity of 1,3,4-Oxadiazoles to Bromodomain factor 3 (TcBDF3) of Trypanosoma cruzi

Tabular Data - 384 B - 11 Variables, 4 Observations -

Table of three concentrations of A1B4 versus fluorescence intensity from the aromatic amino acids of TcBDF3, TcBD3, TcBD2, and TcBDF3m. As a positive binding control, iBET-151 was used, a BET bromodomain inhibitor previously reported to bind to TcBDF3. Tabla de tres concentrac...

hmmer_commands.sh

Oct 16, 2024 - Experimental data on the binding and activity of 1,3,4-Oxadiazoles to Bromodomain factor 3 (TcBDF3) of Trypanosoma cruzi

Shell Script - 147 B -

Commands used in the HMMER v3.4 search algorithm. Comandos utilizados en el algoritmo de búsqueda HMMER v3.4.

hmmsearch_output_dom.tab

Oct 16, 2024 - Experimental data on the binding and activity of 1,3,4-Oxadiazoles to Bromodomain factor 3 (TcBDF3) of Trypanosoma cruzi

Tabular Data - 82.4 KB - 16 Variables, 772 Observations -

Table with the results obtained using the HMMER v3.4 search algorithm. Tabla con los resultados obtenidos utilizando el algoritmo de búsqueda HMMER v3.4.

hmmsearch_output_dom.txt

Oct 16, 2024 - Experimental data on the binding and activity of 1,3,4-Oxadiazoles to Bromodomain factor 3 (TcBDF3) of Trypanosoma cruzi

Plain Text - 142.7 KB -

Output table of the search using the HMMER v3.4 search algorithm. Tabla de salida de la búsqueda utilizando el algoritmo de búsqueda HMMER v3.4.

MTT_cyclic.tab

Oct 16, 2024 - Experimental data on the binding and activity of 1,3,4-Oxadiazoles to Bromodomain factor 3 (TcBDF3) of Trypanosoma cruzi

Tabular Data - 229 B - 4 Variables, 9 Observations -

3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction assay determined cell viability after treatment. Table with absorbance measurements at 540 nm for increasing concentrations of A1B4c and A5B4c. El ensayo de reducción con bromuro de 3-(4,5-dimetiltiaz...

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