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271 to 280 of 294 Results

Ballari_et_al_Supporting_Information_01_T_cruzi_growing_curves.pdf Mar 5, 2024 - Supplementary data for: Amino Acids metabolism as drug target for anti-trypanosomatids drug discovery Adobe PDF - 722.7 KB - MD5: 788733193a5d1ccdd026eba20ae0e960 T cruzi growing curves: effect of the proline analogues on the proliferation of the epimastigote form of T. cruzi Growth curves, dose response curves, and IC50s obtained for treatments of different strains of T. cruzi epimastigotes with variable concentrations of proline analogu...
Ballari_et_al_Supporting_Information_02_Cell_death_experiments.pdf Mar 5, 2024 - Supplementary data for: Amino Acids metabolism as drug target for anti-trypanosomatids drug discovery Adobe PDF - 494.9 KB - MD5: e0f70eccc60536aaffde8227ebd62605 Cell death experiments: cell death analysis for Trypanosoma cruzi epimastigotes. Analysis of cell death and cell cycle arrest mechanisms on T. cruzi epimastigotes caused by treatment with proline analogues. To analyse cell death mechanism, T. cruzi, strain CL14 epimastigotes (2...
Ballari_et_al_Supporting_Information_03_Compounds_Characterization.pdf Mar 5, 2024 - Supplementary data for: Amino Acids metabolism as drug target for anti-trypanosomatids drug discovery Adobe PDF - 3.1 MB - MD5: af9f6713537b5c3bb1a9edf1aa659f7c Compounds characterization. UV-vis characterization of the fluorescent proline analogue 1-NBD, as well as NMR spectral characterization of all final compounds. Prediction of physicochemical properties of fluorescent analogues was performed using molinspiration platform (http://...
01_FPRs_Fld_y_Fds_Ver3_aminoacid_sequences.txt Oct 2, 2023 - Datos espectroscópicos, cinéticos y fisiológicos de las dos Ferredoxin/flavodoxin-NADP(H) reductasas del aislamiento extremófilo Acinetobacter Ver3 Texto sin formato - 1.2 KB - MD5: 4cba3480ca01d60319b6c33481466e6c Aminoacid sequences under study from Acinetobacter Ver3
02_FPR1_diferential_spectra.tab Oct 2, 2023 - Datos espectroscópicos, cinéticos y fisiológicos de las dos Ferredoxin/flavodoxin-NADP(H) reductasas del aislamiento extremófilo Acinetobacter Ver3 Tabular Data - 476.9 KB - 64 Variables, 1362 Observations - UNF:6:3g/0qbdlPBYhkd0QTSBpSA== FPR1 absorbance data as a function of NADP concentration (0-1)mM. Wavelength range 300-600 nm.
03_FPR2_diferential_spectra.tab Oct 2, 2023 - Datos espectroscópicos, cinéticos y fisiológicos de las dos Ferredoxin/flavodoxin-NADP(H) reductasas del aislamiento extremófilo Acinetobacter Ver3 Tabular Data - 465.8 KB - 62 Variables, 1353 Observations - UNF:6:C7vrAsVY94CO5Qy+HM2YcA== FPR2 absorbance data as a function of NADP concentration (0-1)mM. Wavelength range 300-600 nm.
04_Fluorescence_Spectra_FPR1_and_FPR2.tab Oct 2, 2023 - Datos espectroscópicos, cinéticos y fisiológicos de las dos Ferredoxin/flavodoxin-NADP(H) reductasas del aislamiento extremófilo Acinetobacter Ver3 Tabular Data - 18.2 KB - 22 Variables, 107 Observations - UNF:6:8/rcNpTvNQxDWdbYfWA6Sg== Fluorescence intensities of FPR1 and FPR2. Excitation spectra between (400-500) nm, fixed emission wavelength 530 nm. Emission spectra between (490-600) nm, fixed excitation wavelength 450 nm. NADP concentration between ( 0-1) mM.
05_Activity_data.tab Oct 2, 2023 - Datos espectroscópicos, cinéticos y fisiológicos de las dos Ferredoxin/flavodoxin-NADP(H) reductasas del aislamiento extremófilo Acinetobacter Ver3 Tabular Data - 2.2 KB - 13 Variables, 35 Observations - UNF:6:mNvmz5Lr9CQXD7iqyD5jJw== Kinetic measurements of FPR1 and FPR2. Diaphorase activity with DCPIP and ferricianure as substrate. Cytochromo c reductase with FlavodoxinVer3 as substrate.
06_Native_gel_diaphorase.jpg Oct 2, 2023 - Datos espectroscópicos, cinéticos y fisiológicos de las dos Ferredoxin/flavodoxin-NADP(H) reductasas del aislamiento extremófilo Acinetobacter Ver3 Imagen JPEG - 750.4 KB - MD5: c42ab0263ae51bc07dc819d8f51cfb43 Lanes: Soluble extracts from Ver3 cells corresponding to 20 μg (1-4) and 30 μg (7-10) of total soluble protein at DO600nm = 0.2, 0.4, 0.8 and 1.2, respectively. (5) 0.25 μg of purified FPR2ver3, (6) 0.65 μg of purified FPR1ver3.
07_Native_gel_Coomasie.jpg Oct 2, 2023 - Datos espectroscópicos, cinéticos y fisiológicos de las dos Ferredoxin/flavodoxin-NADP(H) reductasas del aislamiento extremófilo Acinetobacter Ver3 Imagen JPEG - 444.5 KB - MD5: 99aba76e9c0ccc708601efebcbc72ee2 Lanes: (7) 0.25 μg of purified FPR2ver3, (6) 0.65 μg of purified FPR1ver3, (5-2) soluble extracts from Ver3 cells corresponding to 20 μg of total soluble protein at DO600nm = 0.2, 0.4, 0.8 and 1.2, respectively.

Ballari_et_al_Supporting_Information_01_T_cruzi_growing_curves.pdf

Mar 5, 2024 - Supplementary data for: Amino Acids metabolism as drug target for anti-trypanosomatids drug discovery

Adobe PDF - 722.7 KB -

T cruzi growing curves: effect of the proline analogues on the proliferation of the epimastigote form of T. cruzi Growth curves, dose response curves, and IC50s obtained for treatments of different strains of T. cruzi epimastigotes with variable concentrations of proline analogu...

Ballari_et_al_Supporting_Information_02_Cell_death_experiments.pdf

Mar 5, 2024 - Supplementary data for: Amino Acids metabolism as drug target for anti-trypanosomatids drug discovery

Adobe PDF - 494.9 KB -

Cell death experiments: cell death analysis for Trypanosoma cruzi epimastigotes. Analysis of cell death and cell cycle arrest mechanisms on T. cruzi epimastigotes caused by treatment with proline analogues. To analyse cell death mechanism, T. cruzi, strain CL14 epimastigotes (2...

Ballari_et_al_Supporting_Information_03_Compounds_Characterization.pdf

Mar 5, 2024 - Supplementary data for: Amino Acids metabolism as drug target for anti-trypanosomatids drug discovery

Adobe PDF - 3.1 MB -

Compounds characterization. UV-vis characterization of the fluorescent proline analogue 1-NBD, as well as NMR spectral characterization of all final compounds. Prediction of physicochemical properties of fluorescent analogues was performed using molinspiration platform (http://...

01_FPRs_Fld_y_Fds_Ver3_aminoacid_sequences.txt

Oct 2, 2023 - Datos espectroscópicos, cinéticos y fisiológicos de las dos Ferredoxin/flavodoxin-NADP(H) reductasas del aislamiento extremófilo Acinetobacter Ver3

Texto sin formato - 1.2 KB -

Aminoacid sequences under study from Acinetobacter Ver3

02_FPR1_diferential_spectra.tab

Oct 2, 2023 - Datos espectroscópicos, cinéticos y fisiológicos de las dos Ferredoxin/flavodoxin-NADP(H) reductasas del aislamiento extremófilo Acinetobacter Ver3

Tabular Data - 476.9 KB - 64 Variables, 1362 Observations -

FPR1 absorbance data as a function of NADP concentration (0-1)mM. Wavelength range 300-600 nm.

03_FPR2_diferential_spectra.tab

Oct 2, 2023 - Datos espectroscópicos, cinéticos y fisiológicos de las dos Ferredoxin/flavodoxin-NADP(H) reductasas del aislamiento extremófilo Acinetobacter Ver3

Tabular Data - 465.8 KB - 62 Variables, 1353 Observations -

FPR2 absorbance data as a function of NADP concentration (0-1)mM. Wavelength range 300-600 nm.

04_Fluorescence_Spectra_FPR1_and_FPR2.tab

Oct 2, 2023 - Datos espectroscópicos, cinéticos y fisiológicos de las dos Ferredoxin/flavodoxin-NADP(H) reductasas del aislamiento extremófilo Acinetobacter Ver3

Tabular Data - 18.2 KB - 22 Variables, 107 Observations -

Fluorescence intensities of FPR1 and FPR2. Excitation spectra between (400-500) nm, fixed emission wavelength 530 nm. Emission spectra between (490-600) nm, fixed excitation wavelength 450 nm. NADP concentration between ( 0-1) mM.

05_Activity_data.tab

Oct 2, 2023 - Datos espectroscópicos, cinéticos y fisiológicos de las dos Ferredoxin/flavodoxin-NADP(H) reductasas del aislamiento extremófilo Acinetobacter Ver3

Tabular Data - 2.2 KB - 13 Variables, 35 Observations -

Kinetic measurements of FPR1 and FPR2. Diaphorase activity with DCPIP and ferricianure as substrate. Cytochromo c reductase with FlavodoxinVer3 as substrate.

06_Native_gel_diaphorase.jpg

Oct 2, 2023 - Datos espectroscópicos, cinéticos y fisiológicos de las dos Ferredoxin/flavodoxin-NADP(H) reductasas del aislamiento extremófilo Acinetobacter Ver3

Imagen JPEG - 750.4 KB -

Lanes: Soluble extracts from Ver3 cells corresponding to 20 μg (1-4) and 30 μg (7-10) of total soluble protein at DO600nm = 0.2, 0.4, 0.8 and 1.2, respectively. (5) 0.25 μg of purified FPR2ver3, (6) 0.65 μg of purified FPR1ver3.

07_Native_gel_Coomasie.jpg

Oct 2, 2023 - Datos espectroscópicos, cinéticos y fisiológicos de las dos Ferredoxin/flavodoxin-NADP(H) reductasas del aislamiento extremófilo Acinetobacter Ver3

Imagen JPEG - 444.5 KB -

Lanes: (7) 0.25 μg of purified FPR2ver3, (6) 0.65 μg of purified FPR1ver3, (5-2) soluble extracts from Ver3 cells corresponding to 20 μg of total soluble protein at DO600nm = 0.2, 0.4, 0.8 and 1.2, respectively.

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